Anti-jc virus antibody assay

Giannecchini: ti. Funding information and disclosures deemed relevant by the authors, if any, are provided at the end of the article. Received May 14; Accepted Dec 1. This is an open access article distributed under the terms of the Creative Commons Attribution-Noncommercial No Derivative 3.

The work cannot be changed in any way or used commercially. This article has been cited by other articles in PMC. Conclusion: Under these experimental conditions, with respect to the observed frequency of JCPyV infection, the sensitivity of the anti-JCPyV antibody assay was lower than expected. JCPyV antibody assay. Open in a separate window. Supplementary Material Data Supplement: Click here to view. Footnotes Supplemental data at Neurology. Risk stratification for progressive multifocal leukoencephalopathy in patients treated with natalizumab.

Mult Scler ; 18 — Ann Neurol ; 68 — Risk of natalizumab-associated progressive multifocal leukoencephalopathy. N Engl J Med ; — Ann Neurol ; 70 — JCV detection in multiple sclerosis patients treated with natalizumab.

J Neurol ; — Asymptomatic reactivation of JC virus in patients treated with natalizumab. Novel mechanisms of immune modulation of natalizumab in multiple sclerosis patients.

J Neuroimmunol ; — Anti-JC virus antibody prevalence in a multinational multiple sclerosis cohort. Mult Scler ; 19 — Viremia is a medical term for viruses present in the bloodstream. Learn about the effects of various viruses along with symptoms and treatment. Experts say regularly washing your hands, not touching your face, and maintaining physical distancing are more effective methods of avoiding COVID Many people wonder how do you know if you have crabs?

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Figure 2. Figure 3. Figure 4. Index Threshold 0. Figure 5. Discussion The current analysis has extended our prior observations to show that in anti-JCV antibody—positive natalizumab-treated patients, higher levels of serum or plasma anti-JCV antibodies, as measured by anti-JCV antibody index, are associated with higher PML risk.

Acknowledgments The study was funded by Biogen Idec, which also provided funding for editorial support in the development of the manuscript.

Authorship T. Potential Conflicts of Interest All authors have equity interests in and are currently or were formerly employed by Biogen Idec. References 1. A randomized, placebo-controlled trial of natalizumab for relapsing multiple sclerosis. N Engl J Med. Efficacy and safety of natalizumab in multiple sclerosis: interim observational programme results.

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JC viremia in natalizumab-treated patients with multiple sclerosis.